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Exome sequencing greatly expedites the progressive research of Mendelian diseases
Xuejun Zhang
Frontiers of Medicine 2014, Volume 8, Issue 1, Pages 42-57 doi: 10.1007/s11684-014-0303-9
The advent of whole-exome sequencing (WES) has facilitated the discovery of rare structure and functionalCombining exome sequencing with linkage studies is one of the most efficient strategies in searchingWe illustrate the workflow of exome capture and sequencing to highlight the advantages of WES.
Keywords: genetics whole-exome sequencing Mendelian disease disease gene
Exploring the cancer genome in the era of next-generation sequencing
Hui Dong, Shengyue Wang
Frontiers of Medicine 2012, Volume 6, Issue 1, Pages 48-55 doi: 10.1007/s11684-012-0182-x
The emergence of next-generation sequencing technologies has led to dramatic advances in cancer genomeThe increased efficiency and resolution of next-generation sequencing greatly facilitate the detectionComprehensive analysis of cancer genomes through approaches of whole genome, exome, and transcriptomesequencing has significantly improved the understanding of cancer biology, diagnosis, and therapy.The present study briefly reviews the recent pioneering studies on cancer genome sequencing and provides
Keywords: next-generation sequencing cancer genome whole genome sequencing exome transcriptome
A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome
Frontiers of Medicine 2023, Volume 17, Issue 2, Pages 330-338 doi: 10.1007/s11684-022-0933-2
Keywords: Clouston syndrome whole exome sequencing GJB6 gene novel variant unique phenotype
Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng
Frontiers of Medicine 2015, Volume 9, Issue 3, Pages 322-330 doi: 10.1007/s11684-015-0408-9
This study systematically evaluates the TCGA whole-transcriptome sequencing data of hepatocellular
Keywords: TCGA whole-transcriptome sequencing HCC liver cancer
Frontiers of Medicine Pages 889-906 doi: 10.1007/s11684-023-0994-x
Keywords: primary central nervous system lymphoma whole-genome sequencing TMSB4X copy number variation
Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou
Frontiers of Medicine 2018, Volume 12, Issue 5, Pages 550-558 doi: 10.1007/s11684-017-0567-y
Keywords: cystic fibrosis pseudo-Bartter syndrome hypokalemic alkalosis CFTR gene mutations infants diagnosis
Frontiers of Medicine 2021, Volume 15, Issue 3, Pages 438-447 doi: 10.1007/s11684-020-0826-1
Keywords: sporadic thoracic aortic dissection exome sequencing gene COL3A1 case–control study extracellular
Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu
Frontiers of Medicine 2018, Volume 12, Issue 1, Pages 23-33 doi: 10.1007/s11684-017-0607-7
Two decades have passed since the first bacterial whole-genome sequencing, which provides new opportunityIn recent years, genome sequencing techniques and bioinformatics have developed rapidly, which has resultedBacterial whole-genome sequencing and bioinformatic computing allow genotyping to satisfy the requirementsIn this review, we outline the significance and summarize the roles of bacterial genome sequencing inWide applications of genome sequencing and data sharing in infectious disease surveillance networks will
Keywords: genome sequencing genomic epidemiology bacteria surveillance infectious diseases
Plastic materials and water sources actively select and shape wastewater plastispheres over time
Frontiers of Environmental Science & Engineering 2022, Volume 16, Issue 11, doi: 10.1007/s11783-022-1580-1
● Wastewater MPs exhibited resistomes and therefore health threats.
Keywords: Microplastics Whole-genome metagenomic sequencing Plastisphere Plastic degradation MHETase
Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi
Engineering 2023, Volume 23, Issue 4, Pages 103-111 doi: 10.1016/j.eng.2022.08.013
Keywords: Polycystic ovary syndrome Infertility Ovulation responses ZNF438 REC114 Whole-exome sequencing
Frontiers of Engineering Management Pages 439-454 doi: 10.1007/s42524-022-0211-7
Keywords: megaproject organizational evolution whole lifecycle management project management team
Cell surface protein engineering for high-performance whole-cell catalysts
Hajime Nakatani,Katsutoshi Hori
Frontiers of Chemical Science and Engineering 2017, Volume 11, Issue 1, Pages 46-57 doi: 10.1007/s11705-017-1609-3
Keywords: cell surface engineering surface display whole-cell catalysts bioprocess
Efficient acetoin production from pyruvate by engineered whole-cell biocatalysis
Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 4, Pages 425-436 doi: 10.1007/s11705-022-2229-0
Keywords: -acetolactate synthetase α-acetolactate decarboxylase Halomonas bluephagenesis whole-cell
Whole-life Thinking and Engineering the Future
Roger Flanagan
Frontiers of Engineering Management 2014, Volume 1, Issue 3, Pages 290-296 doi: 10.15302/J-FEM-2014040
Keywords: whole-life thinking systems thinking complexity chaos risk management through life
Frontiers of Medicine 2022, Volume 16, Issue 2, Pages 240-250 doi: 10.1007/s11684-021-0909-7
Keywords: small RNAs 2′-O-methylation sequencing RT-qPCR
Title Author Date Type Operation
Exome sequencing greatly expedites the progressive research of Mendelian diseases
Xuejun Zhang
Journal Article
Exploring the cancer genome in the era of next-generation sequencing
Hui Dong, Shengyue Wang
Journal Article
A novel variant in the gene in a large Chinese family with a unique phenotype of Clouston syndrome
Journal Article
TCGA whole-transcriptome sequencing data reveals significantly dysregulated genes and signaling pathways
Daniel Wai-Hung Ho,Alan Ka-Lun Kai,Irene Oi-Lin Ng
Journal Article
Analysis of the genomic landscape of primary central nervous system lymphoma using whole-genome sequencing
Journal Article
Clinical characterization and diagnosis of cystic fibrosis through exome sequencing in Chinese infants
Liru Qiu, Fengjie Yang, Yonghua He, Huiqing Yuan, Jianhua Zhou
Journal Article
Identification of variants associated with sporadic thoracic aortic dissection: a case--control study
Journal Article
Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the
Biao Kan, Haijian Zhou, Pengcheng Du, Wen Zhang, Xin Lu, Tian Qin, Jianguo Xu
Journal Article
Plastic materials and water sources actively select and shape wastewater plastispheres over time
Journal Article
Novel Genetic Risk and Metabolic Signatures of Insulin Signaling and Androgenesis in the Anovulation of Polycystic Ovary Syndrome
Xiaoke Wu, Chi Chiu Wang, Yijuan Cao, Jian Li, Zhiqiang Li, Hongli Ma, Jingshu Gao, Hui Chang, Duojia Zhang, Jing Cong, Yu Wang, Qi Wu, Xiaoxiao Han, Pui Wah Jacqueline Chung, Yiran Li, Xu Zheng, Lingxi Chen, Lin Zeng, Astrid Borchert, Hartmut Kuhn, Zi-Jiang Chen, Ernest Hung Yu Ng, Elisabet Stener-Victorin, Heping Zhang, Richard S. Legro, Ben Willem J. Mol, Yongyong Shi
Journal Article
Organizational evolution of project management teams over the whole lifecycle of megaprojects: Case study
Journal Article
Cell surface protein engineering for high-performance whole-cell catalysts
Hajime Nakatani,Katsutoshi Hori
Journal Article